Top 20 Vaccine Filling Machine Manufacturers in 2025
Top 20 Vaccine Filling Machine Manufacturers in 2025
In the realm of pharmaceuticals, few processes are as critical and sensitive as the filling of vaccines. The packaging of these life-saving formulations demands unparalleled precision, sterility, and reliability. Central to this operation is the vaccine filling machine, a sophisticated piece of engineering that sits at the heart of modern pharmaceutical production lines. This article answers the fundamental questions surrounding this vital technology.
What is a Vaccine Filling Machine?
A vaccine filling machine is a highly specialized, fully automated aseptic processing system designed to dispense a precise dosage of a vaccine into vials, syringes, or cartridges in a completely sterile environment. Unlike standard liquid fillers, these machines are built to meet the stringent requirements of Grade A sterile processing, often incorporating isolator or Restricted Access Barrier System (RABS) technology to prevent human and environmental contamination. The design and construction of such precision equipment are the domain of specialized vaccine filling machine manufacturers.
What is the Process of Vaccine Filling?
The vaccine filling process is a meticulously controlled sequence designed to maintain sterility from start to finish:
1. Component Sterilization & Feeding: Empty vials or syringes are sterilized, typically in a washer and tunnel, before
being automatically fed into the filling machine in a sterile state.
2. Aseptic Filling: Within the sterile enclosure, the machine's filling pumps accurately dispense the exact vaccine dose
into each container. This happens in an ISO 5 (Class 100) environment.
3. Stoppering & Sealing: Immediately after filling, rubber stoppers are partially or fully inserted into vials (lyophilization
may require partial stoppering), or caps are placed on syringes to hermetically seal the product.
4. Capping: For vials, aluminum overseals are crimped onto the stoppered vials to ensure a tamper-evident and secure
seal.
5. Discharge: The finished, filled containers are gently discharged from the machine onto a conveyor for subsequent
inspection, labeling, and packaging.
What is a Filling Machine Used in Pharmaceuticals?
While this article focuses on vaccines, filling machines in the pharmaceutical industry are versatile workhorses used for a wide range of products. This includes:
• Small and Large Molecule Injectables: Similar to vaccines, these require high-precision aseptic filling.
• Lyophilized (Freeze-Dried) Products: Machines can be equipped with special stoppering systems for products that
must be freeze-dried after filling.
• Ophthalmic Solutions: Eye drops and other sterile solutions.
• Oral Liquids and Suspensions: Though these often require a lower grade of sterility than injectables.
The expertise to build machines for these diverse applications is held by vaccine filling machine companies that understand cGMP and other global regulatory standards.
Filling Technology and Mechanisms
The choice of filling technology is paramount for accuracy and product integrity:
• Peristaltic Pump Filling: The gold standard for aseptic filling. The product only contacts a single-use, pre-sterilized
silicone tube, eliminating any risk of cross-contamination and making cleaning and validation straightforward.
• Piston-on-Syringe Filling: A piston draws a precise volume from a product tank and dispenses it. While accurate, it
requires more complex cleaning and sterilization procedures (CIP/SIP) between batches.
• Time-Pressure Filling: Less common for critical vaccines, it involves dispensing a liquid over a precise time under
constant pressure.
Advantages and Benefits of Using Filling Machines
The automation of vaccine filling provides immense benefits:
• Uncompromising Sterility & Safety: Isolators and automated processes remove human operators from the critical filling
zone, drastically reducing contamination risks.
• Micro-Dosing Precision: Achieves extremely high accuracy for small, valuable vaccine doses, ensuring every patient
receives the correct potency.
• Regulatory Compliance: Machines are designed and validated to meet strict FDA, EMA, and WHO guidelines for
pharmaceutical manufacturing.
• High-Speed Production: Automated lines can fill hundreds of containers per minute, which is essential for mass
vaccination campaigns and global supply.
• Data Integrity: Modern machines provide complete electronic records of every fill (e.g., via PAT - Process Analytical
Technology) for full traceability and lot control.
Troubleshooting and Maintenance Considerations
Given the critical nature of their output, these machines require rigorous maintenance.
• Common Issues: Dosing inaccuracies (often from pump calibration drift), stoppering faults, and rare sterility breaches
related to barrier integrity.
• Maintenance Best Practices:
◦ Preventive & Predictive Maintenance: Strict adherence to scheduled maintenance, including seal replacements,
pump calibrations, and HEPA/ULPA filter integrity testing.
◦ Full Validation: Equipment must undergo Installation Qualification (IQ), Operational Qualification (OQ), and
Performance Qualification (PQ) to ensure it operates as intended.
◦ CIP/SIP: Regular Clean-in-Place and Sterilize-in-Place cycles are mandatory to maintain aseptic conditions.
◦ Expert Partnership: Maintenance often requires direct support from the vaccine filling machine factory or highly
trained technicians to ensure compliance and avoid prolonged downtime.
The production of these complex machines is a testament to advanced manufacturing. A vaccine filling machine factory is a controlled environment where precision machining, stainless-steel fabrication, and rigorous testing converge to build the equipment that safeguards global health. Choosing the right manufacturer is not just an operational decision but a critical one for public health outcomes.
List of 20 Vaccine Filling Machine Manufacturers
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Address: Room 1905, Youyi Building, Xincheng Avenue, Cixi, Ningbo, Zhejiang, China |
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| Mic Machinery is a global leader among vaccine filling machine manufacturers, known for delivering highly accurate and efficient systems for the pharmaceutical sector. As one of the trusted vaccine filling machine companies, Mic Machinery provides advanced filling, sealing, and capping solutions designed for sterile environments. With a reputation as a reliable vaccine filling machine factory, the company ensures compliance with GMP standards while helping clients scale production effectively. |
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Address: 152 Longquan Bay, Xueyan Town, Wujin, Changzhou, Jiangsu, China |
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| BW Filling Machinery is one of the most established vaccine filling machine manufacturers worldwide. The company focuses on aseptic and sterile filling systems that meet the highest pharmaceutical safety standards. As a top vaccine filling machine company, BW Filling Machinery provides comprehensive solutions, including filling, sealing, and inspection technologies. |
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Address: 2224 Wukesong Road, Sanxing town, Zhangjiagang, Jiangsu, China |
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| Zhangjiagang Mic Machinery is recognized as a premium vaccine filling machine factory, specializing in high-speed and high-precision equipment. Their machines are widely used by pharmaceutical giants for filling vaccines and biologics. The company stands out among vaccine filling machine companies due to its engineering excellence and strong customer support. |
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Address: Böhmerwaldstraße 5, 93073 Neutraubling, Bavaria, Germany |
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| Krones is a renowned German manufacturer and one of the trusted vaccine filling machine manufacturers in the global pharmaceutical industry. The company offers a wide range of sterile filling machines for vials, syringes, and cartridges. As a leading vaccine filling machine company, Krones integrates automation with strict regulatory compliance. |
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Address: 1535 S State Road 39, La Porte, Indiana, United States of America |
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| APACKS is a respected American brand among vaccine filling machine manufacturers, providing customized solutions for sterile and aseptic filling. Their advanced lines combine filling with inspection and packaging systems. As a versatile vaccine filling machine factory, APACKS caters to both large-scale pharma companies and biotech startups. |
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Address: Avenue de la Patrouille de France, 76930 Octeville-sur-Mer, Normandy, France |
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| Sidel is a global leader counted among top vaccine filling machine manufacturers, offering turnkey filling and packaging systems. Their equipment is designed for high precision, sterility, and reliability in critical applications. Sidel is also known as a dependable vaccine filling machine company for its innovation and global service network. |
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Address: 50 Schoolhouse Road Somerset, New Jersey, United States of America |
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| Cozzoli Machine Company is well-regarded among vaccine filling machine companies, delivering state-of-the-art pharmaceutical machinery. Their aseptic filling solutions ensure safe and accurate vaccine production. Cozzoli’s presence as a reliable vaccine filling machine factory is strengthened by decades of engineering expertise. |
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Address: Stuttgarter Straße 130, Waiblingen, Baden-Württemberg, Germany |
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| Syntegon Technology GmbH has built a strong reputation as one of the most innovative vaccine filling machine manufacturers. Their robotic aseptic filling workcells are widely used for vaccine and biologics production. As a pioneering vaccine filling machine company, Syntegon focuses on sterility assurance and flexible manufacturing. |
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Address: 4119 Fordleigh Road Baltimore, Maryland, United States of America |
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| Filamatic is an American manufacturer recognized globally as one of the top vaccine filling machine manufacturers. The company specializes in aseptic filling machines for syringes, vials, and cartridges. As a leading vaccine filling machine factory, Filamatic combines innovation with long-term reliability. |
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Address: Juchostrasse 20, 44143 Dortmund, Germany |
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| KHS GmbH is an established German brand included among reliable vaccine filling machine companies, offering complete lines for injectable products. Their solutions cover filling, closing, and freeze-drying integration. As a trusted vaccine filling machine factory, KHS GmbH serves both multinational corporations and mid-size pharmaceutical producers. |
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Address: 2980 Scott St, Vista, CA 92081, United States |
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| Accutek Packaging Equipment is an American manufacturer known as one of the highly specialized vaccine filling machine manufacturers. Their focus on aseptic filling ensures compliance with strict international pharmaceutical standards. Accutek’s role as a vaccine filling machine company makes it a preferred partner for vaccine production lines. |
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Address: Via Italia, 43, Gessate Milano, Lombardy, Italy |
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| Ronchi Mario S.p.A. is well-known among vaccine filling machine manufacturers for its focus on innovative sterile systems. Their patented technologies ensure safety and efficiency in vaccine production. As a reliable vaccine filling machine factory, the company emphasizes flexibility and contamination prevention. |
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Address: Via G. Garibaldi, 34N, Bonate Sotto, Lombardy, Italy |
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| Comac is recognized among strong vaccine filling machine companies, offering integrated pharmaceutical equipment solutions. Their product range includes filling, lyophilization, and packaging systems. As a growing vaccine filling machine factory, Comac continues to expand internationally. |
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Address: Olympus House, Mill Green Road, Haywards Heath, West Sussex, United Kingdom |
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| Adelphi Packaging Machinery is one of U.K.’s leading vaccine filling machine manufacturers, producing advanced pharmaceutical equipment for global markets. Their systems meet GMP and FDA compliance for sterile applications. As an emerging vaccine filling machine company, Adelphi provides cost-effective solutions with modern automation. |
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Address: N15 W23500 Stone Ridge Drive, Waukesha, Wisconsin, United States of America |
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| Federal Mfg. is an American vaccine filling machine factory, specializing in aseptic processing solutions. They are well-regarded among vaccine filling machine companies for their reliable and affordable equipment. Their global reach makes them a competitive player in the pharmaceutical machinery sector. |
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Address: Hofäckerstraße 9 Crailsheim, Baden-Württemberg, Germany |
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Groninge is a respected name among vaccine filling machine manufacturers. They provide vial washing, sterilization, and filling solutions. As a recognized vaccine filling machine company, Groninge ensures top quality and compliance with international standards. |
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Address: Ko-58 Mameda-Honmachi, Kanazawa, Ishikawa, Japan |
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| Shibuya Corporation is a Japanses company ranked among top vaccine filling machine manufacturers, focusing on innovative aseptic technologies. Their machines are designed for precision and sterile production environments. MShibuya Corporation’s role as a vaccine filling machine factory highlights their commitment to pharmaceutical excellence. |
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Address: 15-39 130th St, College Point, New York, United States of America |
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| Filling Equipment Company is included among reliable vaccine filling machine companies, delivering small- and large-scale aseptic systems. Their machines are known for flexibility and precision dosing. As a specialized vaccine filling machine factory, Filling Equipment Company serves biotech firms and pharmaceutical corporations alike. |
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Barry-Wehmiller Packaging Systems Address: 8020 Forsyth Boulevard, St. Louis, Missouri, United States of America |
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| Barry-Wehmiller Packaging Systems is a trusted American brand among vaccine filling machine manufacturers. Their equipment is recognized for efficiency and ease of use in pharmaceutical environments. As a dedicated vaccine filling machine company, Barry-Wehmiller Packaging Systems ensures quality and reliability across its solutions. |
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Address: 1535 South State Road 39, La Porte, IN 46350, United States |
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| E-PAK Machinery is a U.S.-based supplier included in the list of leading vaccine filling machine manufacturers. They provide versatile filling and packaging systems tailored for sterile liquid applications. As a global vaccine filling machine company, E-PAK is valued for customer support and technical service. |
Global Distribution of Vaccine Filling Machine Manufacturers by Country
| Country | Number of Companies | Share (%) |
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USA | 8 | 40% |
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Germany | 4 | 20% |
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China | 3 |
15% |
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Italy | 2 | 10% |
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France | 1 | 5% |
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United Kingdom | 1 | 5% |
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Japan | 1 | 5% |
List of 4 Vaccine Filling Machine Products
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A vaccine filling machine is designed to accurately fill vaccines into vials, ampoules, or syringes under sterile conditions. It ensures precision, safety, and efficiency, making it essential for pharmaceutical companies in vaccine production and packaging. |
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Automatic Vaccine Filling Machine
An automatic vaccine filling machine is used to precisely fill vaccines into vials, ampoules, or syringes in a fully automated process. It ensures sterile operation, high accuracy, and efficiency, making it ideal for large-scale pharmaceutical vaccine production. |
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A vaccine packing machine is designed to package vaccines into vials, syringes, or cartons safely and efficiently. It ensures sterile handling, accurate packaging, and high productivity, making it essential for pharmaceutical vaccine manufacturing and distribution. |
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High Speed Vaccine Filling Machine
A high-speed vaccine filling machine is built to rapidly and precisely fill vaccines into vials, ampoules, or syringes. It ensures sterile operation, accurate dosing, and large-scale efficiency, making it ideal for mass vaccine production in pharmaceutical industries. |
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